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Exemestane belongs to a group of medicines known as aromatase inhibitors. Aromatase Inhibitors interfere with a substance called aromatase, which is needed to produce the female sex hormones, called oestrogens, especially in postmenopausal women. Reduction in oestrogen levels in the body is a way of treating hormone dependent breast cancer.

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Medical Aromasin Dosage

Within medicine,  Generic Aromasin – Xtane (Exemestane) is approved by doctors the treatment of post-menopausal female breast cancer patients as an adjunctive treatment when first-line treatments (such as Generic Nolvadex) have failed to work. The standard protocol among the medical establishment is that of commencing Generic Aromasin administration approximately 2 – 3 years following the failure of Generic Nolvadex in a patient. This is where Nolvadex administration is to be halted, and the use of Generic Aromasin begins for a determined 5 year period in which Nolvadex is utilized alongside Exemestane.

Exemestane dosages under the aforementioned breast cancer treatment are that of a single 25mg dose daily (prescription guidelines also suggest that Generic Aromasin doses be administered following a meal).

Recommended Dose

The recommended dose of AROMASIN in early and advanced breast cancer is one 25 mg tablet once daily after a meal.

• adjuvant treatment of postmenopausal women with estrogen-receptor positive early breast cancer who have received two to three years of tamoxifen and are switched to AROMASIN for completion of a total of five consecutive years of adjuvant hormonal therapy.
• the treatment of advanced breast cancer in postmenopausal women whose disease has progressed following tamoxifen therapy.

The recommended dose of Exemestane is one 25 mg tablet to be taken once daily, preferably after a meal.

In patients with early breast cancer, treatment with Exemestane should continue until completion of five years of combined sequential adjuvant hormonal therapy (tamoxifen followed by Exemestane), or earlier if tumour relapse occurs.

In patients with advanced breast cancer, treatment with Exemestane should continue until tumour progression is evident.

Generic Aromasin Dosage During Anabolic Steroid Use

As with most/all ancillary compounds, Exemestane cannot be categorized into the three tiers of users (beginner, intermediate, and advanced) as normally outlined and listed in common profiles of the different compounds and drugs. This is due to the fact that GEneric Aromasin is an ancillary drug not particularly used for the purpose of performance enhancement, but instead is utilized to combat or mitigate various Estrogen-related side effects when aromatizable anabolic steroids are utilized.

Generic Aromasin holds several different capabilities of use aside from its Estrogen blocking capabilities, and not only is its Estrogen blocking capabilities a step above the other major aromatase inhibitors, but its ability to increase Testosterone levels is as well. This will be covered in greater detail very shortly, under Aromasin’s use during PCT (Post Cycle Therapy).

For the purpose of Estrogen control during a cycle: It is well established that Exemestane is very effective at reducing total Estrogen levels via the inhibition of the aromatase enzyme. But how much Exemestane is required and how often are factors that are largely dependent on the doses of aromatizable anabolic steroids used, the individual’s sensitivity to aromatase inhibitors, and the rate of aromatization of the anabolic steroids used. With this being said, the general range of Exemestane doses are 12.5 – 1mg daily. As with all aromatase inhibitors, there is always room for adjustment in relation to the user’s experiences at a particular Aromasin dose and dose frequency. Often times, adjustment is necessary with a powerful and very potent aromatase inhibitor such as Aromasin. Aromasin dosages of 12.5mg every other day is enough for Estrogen control, which is commonly utilized among the anabolic steroid using community. Once again, adjustments are a normal part of aromatase inhibitor use.

It is very important for the reader to be reminded to always keep in mind that the use of an aromatase inhibitor is for the purpose of Estrogen control in order to restore circulating Estrogen levels back to normal physiological levels following an increase due to aromatization. Complete reduction and/or elimination of Estrogen levels often result in negative effects on the body.

Store at 25°C (77°F); excursions permitted to 15°–30°C (59°–86°F) [see USP Controlled Room Temperature].

In general, Exemestane is well tolerated and the following side effects observed in patients treated with Exemestane are mainly mild or moderate in nature. Most of the side effects are associated with a shortage of oestrogen (e.g. hot flushes).

Hypersensitivity, inflammation of the liver (hepatitis) and inflammation of the bile ducts of the liver sometimes causing yellowing of the skin (cholestatic hepatitis) may occur. Symptoms include feeling generally unwell, nausea, jaundice (yellowing of the skin and eyes), itching, right sided abdominal pain and loss of appetite

Important things to remember about the side effects of exemestane:

• Most people do not experience all of the side effects listed.
• Side effects are often predictable in terms of their onset and duration.
• Side effects are almost always reversible and will go away after treatment is complete.
• There are many options to help minimize or prevent side effects.
• There is no relationship between the presence or severity of side effects and the effectiveness of the medication.

The following side effects are common (occurring in greater than 30%) for patients taking exemestane:

• Hot Flashes

These side effects are less common side effects (occurring in about 10-29%) of patients receiving exemestane:

• Bone pain/Decreased bone mineral density
• Joint pain (arthralgias)
• Increased sweating
• High blood pressure(hypertension)
• Hair thinning
• Insomnia (sleep problems)
• Nausea(mild)
• Fatigue
• Abdominal pain
• Depression
• Pain

Not all side effects are listed above. Some that are rare (occurring in less than 10% of patients) are not listed here. However, you should always inform your health care provider if you experience any unusual symptoms.

When to contact your doctor or health care provider:

Contact your health care provider immediately, day or night, if you should experience any of the following symptoms:

• Shortness of breath or difficulty breathing
• Having thoughts or feeling like you may want to harm yourself or others

The following symptoms require medical attention, but are not an emergency. Contact your health care provider within 24 hours of noticing any of the following:

• Vaginal bleeding (similar to a period)

Always inform your health care provider if you experience any unusual symptoms.

Precautions:

• Before starting Exemestane treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.).
• Exemestane can cause decreased bone mineral density due to decreases in estrogen levels. Your doctor will monitor your bone mineral density and may prescribe calcium supplements, vitamin D supplements, or other medications to help prevent osteoporosis and bone fractures.
• Do not receive any kind of immunization or vaccination without your doctor’s approval while taking Exemestane.
• Inform your health care professional if you are pregnant or may be pregnant prior to starting this treatment. Pregnancy category X (Exemestane may cause fetal harm when given to a pregnant woman. This drug must not be given to a pregnant woman or a woman who intends to become pregnant. If a woman becomes pregnant while taking Exemestane, the medication must be stopped immediately and the woman given appropriate counseling).
• For both men and women: Use contraceptives, and do not conceive a child (get pregnant) while taking Exemestane. Barrier methods of contraception, such as condoms, are recommended. Discuss with your doctor when you may safely become pregnant or conceive a child after therapy.
• Do not breast feed while taking Exemestane.

Self-Care Tips:

• Take Exemestane after a meal; at about the same time every day.
• Exemestane causes little nausea. But if you should experience nausea, take anti-nausea medications are prescribed by your doctor, and eat small frequent meals. Such on lozenges and chewing gum may also help.
• In general, drinking alcoholic beverages should be kept to a minimum or avoided completely. You should discuss this with your doctor.
• If you are experiencing hot flashes, wearing light clothing, staying in a cool environment, and putting cool cloths on your head may reduce symptoms. Consult your health care provider if these worsen, or become intolerable.
• Acetaminophen or ibuprofen may help relieve discomfort generalized aches and pains. However, be sure to talk with your doctor before taking it.
• Get plenty of rest.
• Maintain good nutrition.
• If you experience symptoms or side effects, be sure to discuss them with your health care team. They can prescribe medications and/or offer other suggestions that are effective in managing such problems.

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