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To understand how Clomid can aid this process, let’s look at how natural testosterone production is regulated.
Testosterone production is regulated by a feedback loop which senses not only testosterone or other androgen levels, but also estrogen levels. This feedback loop includes the hypothalamus, the pituitary, and the testes (often referred to as the HPTA, or hypothalamic-pituitary-testicular axis.)
When the hypothalamus senses low estrogen levels and does not sense high androgen levels, it’s stimulated to signal the pituitary by producing more LHRH, which stands for LH releasing hormone. On receiving this signal, the pituitary produces more LH (luteinizing hormone) which in turn signals the testes to produce more testosterone.
The common dosage for Clomid is 300mg for day 1; 100mg per day for days 2-11; and 50mg/day for days 12-21. However for nonmedical purposes, the suggested dose of the drug is 50-100 mg/day for 4-6 weeks.
Clomid ordinarily is dosed at 50 mg/day. However, it’s important to note that clomiphene has a long half life. Where this has relevance is that when a daily dose is taken, the body will have not only that dose in it, but also an accumulated amount of about five days’ worth of previous doses as well. That’s fine: it results in correct blood levels. Where there can be a problem is when first starting use. If simply taking 50 mg/day from the beginning, there is no such buildup and levels will be low.
To account for this, 300 mg is taken on the first day, as three doses of 100 mg, or optionally six doses of 50 mg. This immediately gets levels to where they should be. Ongoing 50 mg/day dosing will maintain this level.
After day 1, doses of more than 50 mg are not needed and are not recommended. They will not improve results, but may increase adverse side effects.
Clomid is one of the most well-tolerated SERM’s and anti-estrogens on the market, and this applies to both men and women. While it carries a very high threshold of toleration, side effects of Clomid do exist and are possible. However, “possible” is the key word and a very important one. Anytime anabolic steroids are discussed as well as non-steroidal items used by anabolic steroid users, many seem to enjoy implying side effects are assured. This is not the case; in fact, most should be able to use Clomid side effect free.
When it comes to the possible side effects of Clomid, we will find most are fairly rare. Some women who have used the SERM as a fertility aid have experienced ovarian enlargement, but again this is very rare. Other possible side effects of Clomid use include:
- Hot Flashes
- Uterine Bleeding (extremely rare)
- Breast Discomfort