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Tizanidine (tye zan’ i deen) is an imidazoline derivative and is a centrally acting muscle relaxant used for therapy of acute muscle spasms and chronic spasticity.  The mechanism by which tizanidine causes skeletal muscle relaxation is not well known; it appears to act at the level of spinal cord pain reflexes, most likely through activity as a central alpha-adrenergic agonist which results in an decrease in activity of motor neurons.  Tizanidine was approved for use in the United States in 1996 and currently several million prescriptions are filled yearly.

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Tizanidine is a commonly used muscle relaxant that has been linked to rare instances of acute liver injury, a few of which have been fatal.

Tizanidine is a short-acting muscle relaxer. It works by blocking nerve impulses (pain sensations) that are sent to your brain.

Tizanidine is used to treat spasticity by temporarily relaxing muscle tone.

Tizanidine may also be used for purposes other than those listed in this medication guide.

Tizanidine is used to help relax certain muscles in your body. It relieves spasms, cramping, and tightness of the muscles caused by medical problems, such as multiple sclerosis or certain injuries to the spine.

Generic Zanaflex does not cure these problems, but it may allow other treatment, such as physical therapy, to be more helpful in improving your condition.

Generic Tizanidine acts on the central nervous system (CNS) to produce its muscle relaxant effects. Its actions on the CNS may also cause some of the medicine’s side effects.

 

Muscle Spasticity

Spasticity associated with multiple sclerosis and spinal cord injury

Initial: 2 mg PO q6-8hr PRN; no more than 3 doses q24hr

Maintenance: Titrate in 2-4 mg/day increments to optimum effect with minimum 1-4 days between dose increments

Not to exceed 36 mg/day; single doses >16 mg not studied

To discontinue taper gradually; decrease by 2-4 mg daily

 

• feeling light-headed, fainting, slow heart rate;
• hallucinations, confusion, unusual thoughts or behavior;
• nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
• burning or pain when you urinate.